Hyper-Coordinated DNA Methylation is Altered in Schizophrenia and Associated with Brain Function

Abstract DNA methylation is an epigenetic biological process that emerging as important mediator of environmental risk effects on the susceptibility severe illness, such schizophrenia. shows coordination across biologically-related genes, but it not known whether resulting network structure has a mediating effect illness risk. Here we identified large gene with hyper-coordinated in several processes are changed brain patients schizophrenia, and associated schizophrenia-relevant function well genetic susceptibility. We found was physiologically coordinated reproducible comprised 6399 genes showed similar architecture blood brain. The core importance for including synaptic strongest common variants Coordinated these decreased samples from donors age-dependent association function. These results support regulatory principle relevant to schizophrenia may be sensitive exposure during specific developmental periods compound predisposition.